Coordinating Political, Legal and Security Affairs Minister Wiranto was attacked by an assailant using some form of sharp weapon during a working visit on Thursday to Pandeglang, Banten.
Indonesia, which is the world's biggest Muslim-majority country, is grappling with a resurgence in militancy and hundreds have detained under tighter new anti-terrorism laws since the beginning of 2019.
Television footage showed the minister slump to the ground beside his auto after the attack in Pandeglang, in Banten province, west of the capital on the island of Java. The minister was reportedly taken to hospital.
Wiranto sustained two stab wounds to his stomach and is conscious and in a stable condition, doctors said.
Indonesia Chief Security Minister Wiranto delivers a speech during a meeting between former militants and victims in Jakarta, Indonesia, February 28, 2018. A husband and wife have been arrested in relation to the attack.
Police say a knife-wielding man has wounded the top security minister, a local police chief and another person in a western province. "He was arrested and the woman fought the police", Madrohim added.
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According to Indonesian national police spokesman Dedi Prasetyo confirmed, an officer, who tried to subdue the suspect, had been injured.
Officers wrestled the suspect to the ground and an image supplied by police showed the suspect, who was wearing a black shirt and light pants, with his arms and legs secured.
Preliminary reports state that the man has been exposed to radical teachings and is affiliated with the Islamic State-linked militant group Jamaah Ansharut Daulah (JAD).
His appointment drew criticism from rights groups for his involvement as chief of the armed forces in the bloody upheaval in East Timor.
In 2003, Wiranto, then already retired from the military, and seven other former military officials were indicted by a United Nations panel for alleged crimes against humanity for atrocities in East Timor after the region voted for independence from Indonesia in a 1999 referendum.