Premier League table-toppers Liverpool could extend their lead over City to nine points with victory on Merseyside.
The Brazil global did not have a shot on target to deal with during an opening period at the San Siro where City took a 1-0 lead through Raheem Sterling before Gabriel Jesus missed a penalty.
Mane was the hero of the hour after striking deep into injury time for the Reds against Aston Villa, but saw yellow earlier int he match for simulation.
"I'm not sure if it's possible".
"Sometimes he is diving, sometimes he has this talent to score incredible goals in the last minute", said the City boss to BBC Sport.
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Douglas also showed support for Gase, despite many frustrated fans already calling for the coach to be fired. Adams has 39 combined tackles, five passes defended, and an interception in seven games this season.
"My son and my daughter all the time when they [Liverpool] win in the last minutes, ask me how lucky they are and I say at the time 'it's not lucky, '" Guardiola told a news conference on Tuesday.
"If the "dive" will give me a penalty then I will do it!"
"But it was far from my intention to say that Sadio Mane is that type of player".
But he believes Guardiola's worries are more to do with Liverpool's strengths than anything to do with diving.
"Of course like Jurgen said he knows Sadio better than me". I go game by game, (we) will try to win tomorrow ... Hopefully I can clarify everything for Jürgen. City were left bemused when no arrests were made over the bus attack at the Champions League match, which Liverpool won 3-0.
"So I think we played already a few big games in this season and for sure City as well will be a big game".
"I have enough to do to think about us and deal with all these things". If we get there then that would be incredible, one more year (through).