The alarming uptick also prompted the county government to ban all fireworks displays and close the county's beaches.
On Wednesday, Orange County confirmed five additional coronavirus-related deaths and 570 new COVID-19 cases.
"Closing the beaches and banning fireworks during this important summer vacation weekend was an incredibly hard decision to make, but it is the responsible decision to protect public health and protect our residents from a deadly virus", said Barbara Ferrer, Los Angeles County Director.
Garfield, the state's least populous county, remains the only county without a reported case.
"The rising patient volume in our hospitals will likely fill all of the intensive care unit beds that are now available", County Health Public Services Director Dr. Christina Ghaly said.
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Meanwhile, the Lost Hills Sheriff's Station announced on Facebook on Monday that it will patrol the beaches over the weekend of July 4.
And, with Los Angeles County closing its beaches for the weekend, there's concern that people would try to come to Ventura County, packing its beaches as well as streets in coastal communities. In total, more than 100 00 0 cases have were identified in Los Angeles County.
The state has set a desired standard average of 25 positive cases per 100,000 over a 14-day period and a seven-day average positive test rate of 8%.
Across Florida, the case count hits 146,341 with 3,447 deaths, according to the Florida Department of Health.
County public health director Barbara Ferrer said Monday restaurants and bars continue to struggle with fully adhering to all of the safety protocols for operating. Testing results are available for more than 1,089,000 individuals, with 9 percent of people testing positive.